Sterile syringe filling

Processing syringe-based products is a core capability of our aseptic filling services. Explore the wide range of configurations we offer, our state-of-the-art facilities, and comprehensive approach to aseptic syringe filling.

Sterile filling of syringes
Syringe filling line

Expert support for a versatile format

At Vetter, we’re proud to be recognized for the world-class aseptic syringe filling services we provide. Our support spans many different forms of this trusted container type, all of which we fill at the highest possible quality standards.

Our syringe filling facilities can process either bulk or pre-sterilized syringes as needed, including both single and dual-chamber systems.

Key steps in syringe filling (bulk)

Thumbnail of video showing process of sterile syringe filling

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Syringes getting washed in washing machine
Washing
Siliconization of syringes before filling process
Siliconization
Syringes enter dry heat tunnel for sterilization
Sterilization
V-OVS Closure Setting
Closure setting
Close up of sterile syringe filling
Syringe filling
Placement of stopper
Stopper placement
Visual inspection after filling process
Visual inspection
Clinical sterile filling of syringes at Chicago site
Vetter Development Service

Sterile syringe filling for clinical products

Our clinical manufacturing sites in Chicago and Ravensburg can both produce high-quality clinical trial material in pre-sterilized syringes for any clinical development phase.

Technical capabilities

  • cGMP aseptic syringe filling
  • RABS for maximum process security
  • Fully automated tub handling
Vetter Development Service Chicago: Early-stage clinical products
Vetter development service office in Chicago, USA

Equipment:

Filling unit for pre-sterilized syringes

Formats:

  • Single-chamber pre-sterilized syringes
  • Qualified formats: 1 mL long glass, 2.25 mL glass

Fill volume:

Range: 0.1-2.25 mL

More Details

Vetter Development Service Ravensburg: Late-stage clinical products
Vetter development service office in Ravensburg, Germany

Equipment:

Multiple filling units for syringes

Formats:

  • Single-chamber syringes (pre-sterilized & bulk)
  • Dual-chamber syringes (liquid/lyo)

Fill volume:

Multiple formats possible, depending on syringe system

Filled syringe at patient site
Secure your global product supply

Commercial sterile syringe filling

Home to a total of 12 aseptic filling lines, our facilities at Schuetzenstrasse, Ravensburg Vetter South, and Vetter Langenargen can process multiple different syringe formats in a wide range of batch sizes.

Technical capabilities

  • cGMP aseptic filling at large scale
  • 100% visual inspection (manual or automated)
Single-chamber bulk syringes (liquid)
Single chamber syringe with v-ovs

Sites & resources:

  • Sites: Schuetzenstrasse, Langenargen
  • Resources: 6 syringe filling lines

Closure systems:

  • V-OVSⓇ
  • RNS/NS
  • Tip Cap

Currently implemented formats*:

0.5 mL, 1 mL, 1 mL long, 1.5 mL, 2.25 mL, 3 mL, 5 mL, 10 mL

 

*Changes and adaptations to format parts and packaging materials are possible. The requests need to be evaluated and reviewed with project management prior to proposal submission.

Single-chamber pre-sterilized syringes (liquid)
    Presterilized syringes in tub

    Sites & resources

    • Sites: Schuetzenstrasse, Langenargen, Ravensburg Vetter South
    • Resources: 3 syringe filling lines

    Closure systems:

    • RNS/NS
    • RTC/PRTC
    • Tip Cap

    Currently implemented formats*:

    1 mL, 1 mL long, 1.25 mL, 1.5 mL, 2.25 mL, 3 mL
     

    *Changes and adaptations to format parts and packaging materials are possible. The requests need to be evaluated and reviewed with project management prior to proposal submission.

    Dual-chamber syringe systems
    Dual-chamber syringe with V-OVS closure system

    Sites & resources:

    • Sites: Schuetzenstrasse, Langenargen, Ravensburg Vetter South
    • Resources: 3 syringe filling lines

    Closure systems:

    V-OVSⓇ

    Currently implemented formats*:

    • Lyo 3S
    • Lyo 3N 80
    • Lyo 3N 120

     

    *Changes and adaptations to format parts and packaging materials are possible. The requests need to be evaluated and reviewed with project management prior to proposal submission.

    John Moore Kontakt

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